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ImmunologicIsoniazid-induced lupus-like reactions have been reported with an incidence of approximately 1%. Public Health Service Surveillance Study of 13,838 persons taking isoniazid, there were 8 deaths among 174 cases of hepatitis. HepaticHepatitis has been reported in less than 5% of patients receiving isoniazid alone. Mild hepatic dysfunction, evidenced by mild and transient elevation of serum transaminase levels occurs in 10 to 20 percent of patients taking isoniazid. In general, death due to isoniazid hepatotoxicity occurs more frequently in women than men.
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